Aminoglycoside administration advice

Aminoglycosides have traditionally been administered by intravenous infusion; however, there is evidence that supports administration of gentamicin and tobramycin by intravenous injection over 3 to 5 minutes. There are limited data for amikacin administration by intravenous injection.

For patients with septic shock or requiring intensive care support, administer:

• gentamicin or tobramycin by intravenous injection over 3 to 5 minutes
• amikacin as per local hospital protocol.

Further advice on administration of aminoglycosides can be found in the Australian Injectable Drugs Handbook¹.