Aminoglycoside use in patients with altered pharmacokinetics

Patients with altered pharmacokinetics lists patient groups with altered pharmacokinetics (eg drug clearance, drug distribution). These patient groups may require modified aminoglycoside dosages – close monitoring is necessary. Expert advice is recommended.

Figure 1. Patients with altered pharmacokinetics
  • Critically ill patients with sepsis or septic shock.
  • Patients with augmented renal clearance [NB1].
  • Patients undergoing dialysis.
  • Patients with severe burns.
  • Patients with cystic fibrosis.
  • Pregnant people.
  • Patients with ascites.
  • Patients with advanced age.
  • Oncology patients receiving nephrotoxic chemotherapyLlanos-Paez 2017.
  • Patients with obesityBoyd 2016.
Note:

NB1: Augmented renal clearance is a term used to describe the enhanced renal function seen in critically ill patients. The use of unadjusted doses of renally eliminated antimicrobials in these patients may result in treatment failureMahmoud 2017.