Approach to vancomycin dosing and monitoring in adults

The approach to vancomycin dosing and monitoring in adults is summarised in Approach to vancomycin dosing and monitoring in adults .

Figure 1. Approach to vancomycin dosing and monitoring in adults
Intermittent vancomycin dosing in critically ill adultsIntermittent vancomycin dosing in noncritically ill adultsVancomycin monitoring and dosage adjustment in adultsDetermining vancomycin drug exposure in adultsMeasuring vancomycin trough plasma concentration in adults
Note:

AUC24 = area under the concentration–time curve over a 24-hour period

NB1: If available and appropriate for the patient population, model-informed precision dosing may be used for the first 48 hours of therapy.

NB2: Decisions about vancomycin monitoring (including the timing of plasma concentration measurement) should be made at the time of prescribing.

NB3: Augmented renal clearance is a term used to describe the enhanced renal function seen in critically ill patients. The use of unadjusted doses of renally eliminated antimicrobials in these patients may result in treatment failureMahmoud 2017.