Endocarditis caused by enterococci resistant to penicillin but susceptible to gentamicin
For adults and children with native or prosthetic valve enterococcal endocarditis resistant to penicillin but susceptible to gentamicin, use:
vancomycin intravenously for 6 weeks; for initial dosing, see Intermittent vancomycin dosing for noncritically ill adults or Intermittent vancomycin dosing for young infants and children vancomycin vancomycin vancomycin
PLUS
gentamicin (adult and child) 1 mg/kg intravenously, 8-hourly for 6 weeks (monitor plasma concentration; see Principles of aminoglycoside use)1. gentamicin gentamicin gentamicin
Ceftriaxone does not have a role in the treatment of penicillin-resistant enterococcal endocarditis.
1 For adults with obesity (body mass index 30 kg/m2 or more), use lean body weight to calculate the dose. For children with obesity, use adjusted body weight to calculate the dose.Return