Standard regimens for local infection associated with a peripheral intravenous catheter where bloodstream infection is unlikely

For adults and children with a suspected local infection associated with a peripheral intravenous catheter where bloodstream infection is clinically unlikely, after taking samples for culture, use:

1dicloxacillin 500 mg (child: 12.5 mg/kg up to 500 mg) orally, 6-hourly; see below for duration of therapy. For dosage adjustment in adults with kidney impairment, see dicloxacillin dosage adjustment dicloxacillin dicloxacillin dicloxacillin

OR

1flucloxacillin 500 mg (child: 12.5 mg/kg up to 500 mg) orally, 6-hourly; see below for duration of therapy. For dosage adjustment in adults with kidney impairment, see flucloxacillin oral dosage adjustment. flucloxacillin flucloxacillin flucloxacillin

For patients at increased risk of methicillin-resistant S. aureus (MRSA) infection, use:

1trimethoprim+sulfamethoxazole 160+800 mg (child 1 month or older: 4+20 mg/kg up to 160+800 mg) orally, 12-hourly; see below for duration of therapy. For dosage adjustment in adults with kidney impairment, see trimethoprim+sulfamethoxazole dosage adjustment trimethoprim + sulfamethoxazole trimethoprim+sulfamethoxazole trimethoprim+sulfamethoxazole

OR

2clindamycin 450 mg (child: 10 mg/kg up to 450 mg) orally, 8-hourly; see below for duration of therapy. clindamycin clindamycin clindamycin

The results of culture and susceptibility testing guide ongoing therapy. The duration of therapy depends on the results of culture and susceptibility testing, but generally a total duration of 5 days following cannula removal is sufficient.