Once-daily or less frequent aminoglycoside dosing: plasma concentration monitoring in neonates

Seek expert advice on aminoglycoside plasma concentration monitoring in neonates. Area under the concentration–time curve (AUC) monitoring in neonates is less established than in adults. AUC calculation software with neonate-specific pharmacokinetic models is available; however, this software is not widely used in clinical practice. Manual AUC calculation is limited by the requirement for repeated blood sampling, which can be difficult because of the small blood volume of some neonates. Some experts prefer to adjust the dosing interval based on a single aminoglycoside plasma concentration.