Native bone and joint infection caused by Enterobacterales and Pseudomonas species
In adults and children with native bone and joint infection caused by Enterobacterales or Pseudomonas species, intravenous therapy should be guided by the results of culture and susceptibility testing – seek expert advice for antibiotic choice.
In adults and children with native bone and joint infection caused by susceptible Enterobacterales and Pseudomonas species, when it is appropriate to switch to oral therapy, use:
ciprofloxacin 750 mg (child: 20 mg/kg up to 750 mg) orally, 12-hourly12. For dosage adjustment in adults with kidney impairment, see ciprofloxacin oral dosage adjustment. ciprofloxacin ciprofloxacin ciprofloxacin
1 An oral liquid formulation of ciprofloxacin is not commercially available; for formulation options for children or people with swallowing difficulties, see Don’t Rush to Crush, which is available for purchase from the Advanced Pharmacy Australia website or through a subscription to eMIMSplus.Return
2 Ciprofloxacin is not licensed for use in children on the basis of animal studies that showed an adverse effect on cartilage development with quinolone use; however, clinical trial data suggest that adverse musculoskeletal events are usually mild and short term, similar to those observed in adults. Ciprofloxacin can be used in children when it is the drug of choice.Return