Practical information on using flucytosine

Flucytosine is used in combination with amphotericin B for synergistic activity against Cryptococcus neoformans and Cryptococcus gattii.

Bone marrow toxicity is associated with high plasma concentrations of flucytosine, which often occur in patients with impaired kidney function. Therefore, plasma concentration monitoring is necessary (see Monitoring flucytosine blood concentrations). Perform a full blood count regularly in all patients receiving flucytosine to detect bone marrow suppression.