Antiretroviral drug interactions

Antiretroviral drugs, especially protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), and boosting drugs (cobicistat and ritonavir) interact with many drugs (including other antiretroviral drugs). The cytochrome P450 enzyme system is responsible for the metabolism of many antiretroviral drugs and is the main mechanism of drug interactions. Interactions can also occur due to other mechanisms (eg reduced absorption with acid-reducing drugs). Always check for drug interactions before prescribing antiretroviral drugs for the treatment or prevention of HIV infection, or when changing drug therapy for a person taking antiretrovirals.

In addition to standard drug interaction references, consult specialised resources such as the University of Liverpool (UK) HIV Drug Interactions.