Diagnosing salivary gland infections
Swelling of a parotid, submandibular or sublingual salivary gland may indicate salivary gland infection; however, a noninfective cause of swelling (eg salivary gland obstruction) is more likely. Potential causes of salivary gland swelling outlines potential causes of salivary gland swelling.
Conditions that can present in a similar way to salivary gland swelling includes benign masseteric hypertrophy, lymphadenopathy and acute odontogenic infection. Acute spreading odontogenic infections must be considered as a cause of swelling of the floor of the mouth or the submandibular gland; acute odontogenic infections require urgent assessment and intervention.
Investigations or imaging (eg ultrasound, computed tomography [CT]) may be necessary to determine the diagnosis.
Inflammatory
- acute bacterial infection (acute suppurative sialadenitis) caused by Staphylococcus aureus, streptococci or mixed anaerobes
- viral infections (eg mumps, coxsackievirus infection, Epstein-Barr virus infection)
- chronic infections (eg tuberculosis, actinomycosis)
- autoimmune disease (eg Sjögren syndrome)
Obstruction within the glands
- stones (sialolithiasis)
- trauma
- mucous retention (ranula)
- tumours obstructing the duct
Metabolic
- obesity
- hypothyroidism
- disorders of alcohol use and alcohol related liver disease
- malnutrition (eg eating disorder)
Tumours
- benign (eg pleomorphic adenoma, monomorphic adenoma)
- malignant (eg mucoepidermoid carcinoma, adenoid cystic carcinoma, adenocarcinoma, lymphoma)
Drug and food hypersensitivity