Diagnosing salivary gland infections

Swelling of a parotid, submandibular or sublingual salivary gland may indicate salivary gland infection; however, a noninfective cause of swelling (eg salivary gland obstruction) is more likely. Potential causes of salivary gland swelling outlines potential causes of salivary gland swelling.

Conditions that can present in a similar way to salivary gland swelling includes benign masseteric hypertrophy, lymphadenopathy and acute odontogenic infection. Acute spreading odontogenic infections must be considered as a cause of swelling of the floor of the mouth or the submandibular gland; acute odontogenic infections require urgent assessment and intervention.

Investigations or imaging (eg ultrasound, computed tomography [CT]) may be necessary to determine the diagnosis.

Figure 1. Potential causes of salivary gland swelling

Inflammatory

Obstruction within the glands

  • stones (sialolithiasis)
  • trauma
  • mucous retention (ranula)
  • tumours obstructing the duct

Metabolic

  • obesity
  • hypothyroidism
  • disorders of alcohol use and alcohol related liver disease
  • malnutrition (eg eating disorder)

Tumours

  • benign (eg pleomorphic adenoma, monomorphic adenoma)
  • malignant (eg mucoepidermoid carcinoma, adenoid cystic carcinoma, adenocarcinoma, lymphoma)

Drug and food hypersensitivity