Oral therapy for nontyphoidal Salmonella enteritis

If antibiotic therapy is indicated for nontyphoidal Salmonella enteritis, and oral therapy is appropriate, useWilliamson, 2018:

1azithromycin 1 g (child: 20 mg/kg up to 1 g) orally on the first day, then 500 mg (child: 10 mg/kg up to 500 mg) orally, daily for a further 4 days; patients with immune compromise may require longer duration of therapy – seek expert advice azithromycin azithromycin azithromycin

OR

1ciprofloxacin 500 mg (child: 12.5 mg/kg up to 500 mg) orally, 12-hourly for 5 days12; patients with immune compromise may require longer duration of therapy – seek expert advice. For dosage adjustment in adults with kidney impairment, see ciprofloxacin oral dosage adjustment. ciprofloxacin ciprofloxacin ciprofloxacin

For nontyphoidal Salmonella susceptible to amoxicillin, useWen, 2017:

amoxicillin 1 g (child: 30 mg/kg up to 1 g) orally, 8-hourly for 5 days; patients with immune compromise may require longer duration of therapy – seek expert advice. For dosage adjustment in adults with kidney impairment, see amoxicillin dosage adjustment. amoxicillin amoxicillin amoxicillin

1 Ciprofloxacin is not licensed for use in children on the basis of animal studies that showed an adverse effect on cartilage development with quinolone use; however, clinical trial data suggest that adverse musculoskeletal events are usually mild and short term, similar to those observed in adults. Ciprofloxacin can be used in children when it is the drug of choice.Return
2 An oral liquid formulation of ciprofloxacin is not commercially available; for formulation options for children or people with swallowing difficulties, see Don’t Rush to Crush, which is available for purchase from the Advanced Pharmacy Australia website or through a subscription to eMIMSplus.Return