Standard regimen for native valve endocarditis caused by methicillin-susceptible staphylococci
For native valve endocarditis caused by methicillin-susceptible staphylococci in adults and children, use:
flucloxacillin 2 g (child: 50 mg/kg up to 2 g) intravenously, 4-hourly for 4 to 6 weeks; see advice on duration of therapy. For dosage adjustment in adults with kidney impairment, see flucloxacillin intravenous dosage adjustment. flucloxacillin flucloxacillin flucloxacillin
Some strains of S. aureus in Australia are penicillin-susceptible. If penicillin susceptibility is confirmed by a clinical microbiologist, consider using benzylpenicillin – seek expert advice.
The addition of gentamicin to the treatment regimen for native valve endocarditis is not necessary since it has not been shown to improve outcomes and may be associated with toxicity.