Persistent urethritis symptoms despite treatment

If urethritis symptoms persist or worsen despite treatment, consider:

• the timeframe; it may take a few weeks for symptoms to completely resolve after successful treatment
• testing for Mycoplasma genitalium (if not already done)
• infection with an alternative pathogen (eg viral causes of urethritis if dysuria is prominent)
• infection with a resistant pathogen
• nonadherence to therapy
• reinfection; the index case and sexual partners may require retreatment.