Androgen replacement for adrenal insufficiency

If a patient with adrenal insufficiency remains symptomatic despite optimised glucocorticoid and mineralocorticoid replacement, a trial of androgen replacement therapy with dehydroepiandrosterone (DHEA) can be considered. DHEA replacement has been reported to improve sexual function in women, and general wellbeing in women and men. It may also increase lean body mass and bone density. However, these benefits have not been shown consistently, and DHEA replacement is not routinely recommended. Seek specialist advice.