Hypercalcaemia caused by sarcoidosis or other granulomatous disorders

Hypercalcaemia caused by sarcoidosis or other granulomatous disorders is associated with an inappropriately high concentration of 1,25-dihydroxyvitamin D (calcitriol). Seek expert advice for management. In addition to rehydration, prednisolone (or prednisone) is effective. A suitable regimen is:

Continue prednisolone (or prednisone) therapy until the total serum calcium concentration corrected for albumin is within the normal range and hypercalciuria has resolved. Withdraw therapy by tapering the dose to avoid adrenal insufficiency (see Adrenocortical suppression).