Methotrexate therapy for maintenance management of Crohn disease

Methotrexate can be considered as an alternative immunomodulatory therapy for maintenance management of Crohn disease. For the steps that should be undertaken before starting methotrexate therapy, see Considerations before starting immunomodulatory therapy in the Rheumatology guidelines—the considerations are the same as for rheumatological diseases. Use:

Immunomodulatory drugs are associated with significant adverse effects. Monitor carefully for complications, especially during the first 3 months of therapy. For factors to consider when reviewing the patient after immunomodulator therapy has started, see Considerations during immunomodulatory therapy in the Rheumatology guidelines—the considerations are the same as for rheumatological diseases.