Key references: Management of functional constipation in adults

  • Ansell J, Butts CA, Paturi G, Eady SL, Wallace AJ, Hedderley D, et al. Kiwifruit-derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study. Nutr Res 2015;35(5):401-8. https://www.ncbi.nlm.nih.gov/pubmed/25931419
  • Aziz I, Whitehead WE, Palsson OS, Tornblom H, Simren M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol 2020;14(1):39-46. https://www.ncbi.nlm.nih.gov/pubmed/31893959
  • Eady SL, Wallace AJ, Butts CA, Hedderley D, Drummond L, Ansell J, et al. The effect of 'Zesy002' kiwifruit (Actinidia chinensis var. chinensis) on gut health function: a randomised cross-over clinical trial. J Nutr Sci 2019;8:e18. https://www.ncbi.nlm.nih.gov/pubmed/31080591
  • Kindleysides S, Kuhn-Sherlock B, Yip W, Poppitt SD. Encapsulated green kiwifruit extract: a randomised controlled trial investigating alleviation of constipation in otherwise healthy adults. Asia Pac J Clin Nutr 2015;24(3):421-9. https://www.ncbi.nlm.nih.gov/pubmed/26420182
  • Reynolds A, Mann J, Cummings J, Winter N, Mete E, Te Morenga L. Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. Lancet 2019;393(10170):434-45. https://www.ncbi.nlm.nih.gov/pubmed/30638909
  • Serra J, Pohl D, Azpiroz F, Chiarioni G, Ducrotte P, Gourcerol G, et al. European society of neurogastroenterology and motility guidelines on functional constipation in adults. Neurogastroenterol Motil 2020;32(2):e13762. https://www.ncbi.nlm.nih.gov/pubmed/31756783
  • Weir I, Shu Q, Wei N, Wei C, Zhu Y. Efficacy of actinidin-containing kiwifruit extract Zyactinase on constipation: a randomised double-blinded placebo-controlled clinical trial. Asia Pac J Clin Nutr 2018;27(3):564-71. https://www.ncbi.nlm.nih.gov/pubmed/29737803