Other therapies for functional dyspepsia

Patients with symptoms suggestive of functional dyspepsia should be screened for Helicobacter pylori infection, and if present, eradication should be strongly considered (see Indications for H. pylori testing and eradication therapy). In approximately 5% of patients with functional dyspepsia the symptoms may be attributable to H. pylori; in these patients H. pylori eradication therapy may reduce symptomsKoletzko, 2019.

Prokinetic drug therapy for functional dyspepsia is only marginally more effective than placebo. A trial of as-needed therapy may be worthwhile if the patient’s main symptom is a feeling of discomfort and bloating, but it should be discontinued if ineffective. Use:

domperidone 10 mg orally, up to 3 times daily before meals if required1Therapeutic Goods Administration, 2012. domperidone domperidone domperidone

Some evidence suggests that the herbal preparation Iberogast (also known as STW5) may have short-term efficacy for functional dyspepsiavon Arnim, 2007.

1 Evidence shows an increased risk of serious cardiac adverse effects (ventricular arrhythmias, sudden cardiac death) from domperidone at doses over 30 mg daily, and in patients older than 60 years. For more information, see the Australian Therapeutic Goods Administration (TGA) Medicines Safety Update.Return