Rifabutin-based triple therapy in adults

Rifabutin-based triple therapy is usually third choice salvage therapy for H. pylori eradication; generally, quinolone-based triple therapy and bismuth-based quadruple therapy are preferred. Use:

a proton pump inhibitor orally, twice daily for 10 days

1esomeprazole 20 mg orally, twice daily for 10 days esomeprazole esomeprazole esomeprazole

OR

1lansoprazole 30 mg orally, twice daily for 10 days lansoprazole lansoprazole lansoprazole

OR

1omeprazole 20 mg orally, twice daily for 10 days omeprazole omeprazole omeprazole

OR

1pantoprazole 40 mg orally, twice daily for 10 days pantoprazole pantoprazole pantoprazole

OR

1rabeprazole 20 mg orally, twice daily for 10 days rabeprazole rabeprazole rabeprazole

PLUS

amoxicillin 1 g orally, twice daily for 10 days amoxicillin amoxicillin amoxicillin

PLUS

rifabutin 150 mg orally, twice daily for 10 days¹. rifabutin rifabutin rifabutin

Eradication rates between 65 and 80% have been reported with this regimen.

¹ Rifabutin is not approved by the Therapeutic Goods Administration (TGA) for this indication. See the TGA website for current information.Return