Key references: Management of opioid-induced constipation in adults

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  • Farmer AD, Drewes AM, Chiarioni G, De Giorgio R, O'Brien T, Morlion B, et al. Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European Gastroenterol J 2019;7(1):7-20. https://www.ncbi.nlm.nih.gov/pubmed/30788113
  • Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R. Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol 2018;3(3):203-12. https://www.ncbi.nlm.nih.gov/pubmed/29870734
  • Ginex PK, Hanson BJ, LeFebvre KB, Lin Y, Moriarty KA, Maloney C, et al. Management of opioid-induced and non-opioid-related constipation in patients with cancer: systematic review and meta-analysis. Oncol Nurs Forum 2020;47(6):E211-E24. https://www.ncbi.nlm.nih.gov/pubmed/33063777
  • Huang L, Zhou JG, Zhang Y, Wang F, Wang Y, Liu DH, et al. Opioid-induced constipation relief from fixed-ratio combination prolonged-release oxycodone/naloxone compared with oxycodone and morphine for chronic nonmalignant pain: a systematic review and meta-analysis of randomized controlled trials. J Pain Symptom Manage 2017;54(5):737-48 e3. https://www.ncbi.nlm.nih.gov/pubmed/28736104
  • Mehta N, O'Connell K, Giambrone GP, Baqai A, Diwan S. Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review. Postgrad Med 2016;128(3):282-9. https://www.ncbi.nlm.nih.gov/pubmed/26839023
  • Muller-Lissner S, Bassotti G, Coffin B, Drewes AM, Breivik H, Eisenberg E, et al. Opioid-induced constipation and bowel dysfunction: a clinical guideline. Pain Med 2017;18(10):1837-63. https://www.ncbi.nlm.nih.gov/pubmed/28034973
  • Nee J, Zakari M, Sugarman MA, Whelan J, Hirsch W, Sultan S, et al. Efficacy of treatments for opioid-induced constipation: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2018;16(10):1569-84 e2. https://www.ncbi.nlm.nih.gov/pubmed/29374616
  • Nishie K, Yamamoto S, Yamaga T, Horigome N, Hanaoka M. Peripherally acting mu-opioid antagonist for the treatment of opioid-induced constipation: Systematic review and meta-analysis. J Gastroenterol Hepatol 2019;34(5):818-29. https://www.ncbi.nlm.nih.gov/pubmed/30597600
  • Passos M, Takemoto MLS, Corradino GC, Guedes LS. Systematic review with meta-analysis: lubiprostone efficacy on the treatment of patients with constipation. Arq Gastroenterol 2020;57(4):498-506. https://www.ncbi.nlm.nih.gov/pubmed/33331483
  • Sridharan K, Sivaramakrishnan G. Drugs for treating opioid-induced constipation: a mixed treatment comparison network meta-analysis of randomized controlled clinical trials. J Pain Symptom Manage 2018;55(2):468-79 e1. https://www.ncbi.nlm.nih.gov/pubmed/28919541
  • Vijayvargiya P, Camilleri M, Vijayvargiya P, Erwin P, Murad MH. Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation. Aliment Pharmacol Ther 2020;52(1):37-53. https://www.ncbi.nlm.nih.gov/pubmed/32462777