Pyridoxine (vitamin B₆) supplementation in adults

See Clinical aspects of key water-soluble vitamins for the physiological function of pyridoxine (vitamin B₆), and the effects of and risk factors for pyridoxine deficiency. Pyridoxine blood concentration does not need to be measured as the result does not dictate whether supplementation is required.

To treat pyridoxine deficiency in adults, use:

For dosing of pyridoxine in pregnant people with nausea and vomiting, see Nausea and vomiting during pregnancy.

Pyridoxine supplementation may cause peripheral neuropathy, resulting in numbness or tingling in the hands and feet. Long-term use of pyridoxine and the use of pyridoxine dosages above 200 mg daily have been associated with peripheral neuropathy; however, there have been reports of peripheral neuropathy occurring with doses under 50 mg¹Ghavanini, 2014Therapeutic Goods Administration, 2020.