Key references: Other adjuvants used in pain management
Other antiepileptics
Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 2010;17(9):1113–e88. https://pubmed.ncbi.nlm.nih.gov/20402746/
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015;14(2):162–73. https://www.ncbi.nlm.nih.gov/pubmed/25575710
Mucke M, Phillips T, Radbruch L, Petzke F, Hauser W. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2018;3:CD012182. https://www.ncbi.nlm.nih.gov/pubmed/29513392
Stockings E, Campbell G, Hall WD, Nielsen S, Zagic D, Rahman R, et al. Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain 2018;159(10):1932–54. https://www.ncbi.nlm.nih.gov/pubmed/29847469
Wade DT, Collin C, Stott C, Duncombe P. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler 2010;16(6):707–14. https://www.ncbi.nlm.nih.gov/pubmed/20558502
Topical capsaicin for pain management
Derry S, Moore RA. Topical capsaicin (low concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2012;(9):CD010111. https://www.ncbi.nlm.nih.gov/pubmed/22972149
Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2017;1:CD007393. https://www.ncbi.nlm.nih.gov/pubmed/28085183
Mick G, Baron R, Correa-Illanes G, Hans G, Mayoral V, Frias X, et al. Is an easy and reliable diagnosis of localized neuropathic pain (LNP) possible in general practice? Development of a screening tool based on IASP criteria. Curr Med Res Opin 2014;30(7):1357–66. https://www.ncbi.nlm.nih.gov/pubmed/24650347
Nagy I, Friston D, Valente JS, Torres Perez JV, Andreou AP. Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. Prog Drug Res 2014;68:39–76. https://www.ncbi.nlm.nih.gov/pubmed/24941664
Clonidine for pain management
Blaudszun G, Lysakowski C, Elia N, Tramer MR. Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2012;116(6):1312–22. https://www.ncbi.nlm.nih.gov/pubmed/22546966
Wrzosek A, Woron J, Dobrogowski J, Jakowicka-Wordliczek J, Wordliczek J. Topical clonidine for neuropathic pain. Cochrane Database Syst Rev 2015;8:CD010967. https://www.ncbi.nlm.nih.gov/pubmed/26329307
Ketamine for pain management
Barreveld AM, Correll DJ, Liu X, Max B, McGowan JA, Shovel L, et al. Ketamine decreases postoperative pain scores in patients taking opioids for chronic pain: results of a prospective, randomized, double-blind study. Pain Med 2013;14(6):925–34. https://www.ncbi.nlm.nih.gov/pubmed/2378655
Blonk MI, Koder BG, van den Bemt PM, Huygen FJ. Use of oral ketamine in chronic pain management: a review. Eur J Pain 2010;14(5):466–72. https://www.ncbi.nlm.nih.gov/pubmed/19879174
Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, et al. Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev 2018;12:CD012033. https://www.ncbi.nlm.nih.gov/pubmed/30570761
Cohen SP, Bhatia A, Buvanendran A, Schwenk ES, Wasan AD, Hurley RW, et al. Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med 2018;43(5):521–46. https://www.ncbi.nlm.nih.gov/pubmed/29870458
Kvarnstrom A, Karlsten R, Quiding H, Emanuelsson BM, Gordh T. The effectiveness of intravenous ketamine and lidocaine on peripheral neuropathic pain. Acta Anaesthesiol Scand 2003;47(7):868–77. https://www.ncbi.nlm.nih.gov/pubmed/12859309
Kvarnstrom A, Karlsten R, Quiding H, Gordh T. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiol Scand 2004;48(4):498–506. https://www.ncbi.nlm.nih.gov/pubmed/15025615
Schwenk ES, Viscusi ER, Buvanendran A, Hurley RW, Wasan AD, Narouze S, et al. Consensus guidelines on the use of intravenous ketamine infusions for acute pain management from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med 2018;43(5):456–66. https://www.ncbi.nlm.nih.gov/pubmed/29870457
Systemic lidocaine use as an adjuvant for pain management
Bailey M, Corcoran T, Schug S, Toner A. Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety. Pain 2018;159(9):1696–704. https://www.ncbi.nlm.nih.gov/pubmed/29757886
Kvarnstrom A, Karlsten R, Quiding H, Emanuelsson BM, Gordh T. The effectiveness of intravenous ketamine and lidocaine on peripheral neuropathic pain. Acta Anaesthesiol Scand 2003;47(7):868–77. https://www.ncbi.nlm.nih.gov/pubmed/12859309
Kvarnstrom A, Karlsten R, Quiding H, Gordh T. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiol Scand 2004;48(4):498–506. https://www.ncbi.nlm.nih.gov/pubmed/15025615
Lee JT, Sanderson CR, Xuan W, Agar M. Lidocaine for cancer pain in adults: a systematic review and meta-analysis. J Palliat Med 2019;22(3):326–34. https://www.ncbi.nlm.nih.gov/pubmed/30614748
Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis. Br J Anaesth 2016;116(6):770–83. https://www.ncbi.nlm.nih.gov/pubmed/27199310
Weibel S, Jelting Y, Pace NL, Helf A, Eberhart LH, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev 2018;6:CD009642. https://www.ncbi.nlm.nih.gov/pubmed/29864216
Yousefshahi F, Predescu O, Francisco , Asenjo J. The efficacy of systemic lidocaine in the management of chronic pain: a literature review. Anesth Pain Med 2017;7(3):e44732. https://www.ncbi.nlm.nih.gov/pubmed/28856112
Topical lidocaine as an adjuvant for pain management
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015;14(2):162–73. https://www.ncbi.nlm.nih.gov/pubmed/25575710
Orellana Silva M, Yanez V, Hidalgo G, Valenzuela F, Saavedra R. 5% lidocaine medicated plaster use in children with neuropathic pain from burn sequelae. Pain Med 2013;14(3):422–9. https://www.ncbi.nlm.nih.gov/pubmed/23279572
Rousseau V, Morelle M, Arriuberge C, Darnis S, Chabaud S, Launay V, et al. Efficacy and tolerance of lidocaine 5% patches in neuropathic pain and pain related to vaso-occlusive sickle cell crises in children: a prospective multicenter clinical study. Pain Pract 2018;18(6):788–97. https://www.ncbi.nlm.nih.gov/pubmed/29266772
