Antidepressant use in females of childbearing potential

The effectiveness of hormonal contraception is not affected by concurrent antidepressant use; however, some hormonal contraceptives can increase the concentration of amitriptyline and imipramine and the risk of adverse effects and toxicity.

If a patient taking an antidepressant wishes to plan a pregnancy, see Principles of psychotropic use in females of childbearing potential for advice on preconception planning and Antidepressant use during pregnancy for information on antidepressant choice and adverse effects during pregnancy. If as part of the preconception plan, the decision is made to switch antidepressants, see here, or stop the antidepressant, see here.