Considerations in treating bipolar depression in young people

Young people are more susceptible to developing agitation, activation and suicidal thoughts when starting treatment with an antidepressant; this effect has been most often observed with SSRIs. Paroxetine should be avoided in young people because it has been associated with an increased risk of suicidal thoughts and behaviours and other serious adverse events. Antidepressants may induce switch to mania more frequently in young people than adults.

Young people are also at increased risk of antipsychotic adverse effects including extrapyramidal adverse effects, effects due to elevated blood prolactin concentration, and weight gain.

See also Considerations in managing bipolar disorder in young people.