Clozapine-resistant schizophrenia

Between 30 and 70% of patients with treatment-resistant schizophrenia do not respond to clozapine and require further treatment—refer to the psychiatrist overseeing clozapine therapy. Options include combining clozapine with:

• another drug (eg aripiprazole, amisulpride, sodium valproate, fluoxetine)
• electroconvulsive therapy (ECT)
• optimised psychosocial interventions (eg cognitive behavioural therapy [CBT] for psychosis).