Risk factors for calcium pyrophosphate deposition
The main risk factors for calcium pyrophosphate deposition are increasing age and the presence of osteoarthritis.
Other risk factors for calcium pyrophosphate deposition include previous joint injury, primary hyperparathyroidism, haemochromatosis and hypomagnesaemia. Consider checking serum calcium, ferritin and magnesium concentrations, particularly in younger patients with calcium pyrophosphate deposition. Although correction of these risk factors may not affect the course of the joint disease, it is important to prevent other complications.
Loop diuretics, but not thiazide diuretics, appear to be associated with the development of acute calcium pyrophosphate crystal arthritisFelson DT, 2021.
Most cases of chondrocalcinosis are not familial. However, many families with chondrocalcinosis have been reported and many of these appear to have inherited the condition in an autosomal dominant mannerTimms, 2002.