Overview of mixed connective tissue disease

Mixed connective tissue disease combines features of systemic lupus erythematosus (SLE), systemic sclerosis and polymyositis, and some features of rheumatoid arthritis. The female to male ratio is high (up to 16:1) and the age of onset is typically between 20 and 30 years. It is rare, affecting 2 people per 100 000 populationUngprasert, 2016.

The 10-year survival of people with mixed connective tissue disease is around 96%; however, if they have associated pulmonary arterial hypertension (PAH), their prognosis is poor.