Introduction to paracetamol use for musculoskeletal pain
Although paracetamol is generally less effective than nonsteroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain, evidence indicates it has a small beneficial effect for some rheumatological conditions, but no benefit for others. Its favourable safety profile in therapeutic doses justifies a trial of paracetamol for mild to moderate pain. Paracetamol may also be used in combination with NSAIDs to reduce the use of NSAIDs and risk of adverse effects.
When prescribing paracetamol, it is recommended that a trial approach is taken where its efficacy is regularly reviewed and treatment is stopped if management goals are not met (eg improved function and quality of life, a modest reduction in pain) or the patient experiences intolerable adverse effects. For dosage recommendations, see the relevant clinical topic.