Overview of systemic lupus erythematosus (SLE) in children and adolescents
Systemic lupus erythematosus (SLE) is rare in children and adolescents. The prevalence of SLE in children and adolescents is approximately 2 to 26 per 100 000, but higher in Asian and Aboriginal and Torres Strait Islander peoplesGroot, 2017. Females are more commonly affected by SLE than males. The median age at diagnosis is 12.6 years.
Similar to SLE in adults, the clinical course of the disease in children and adolescents is often one of remission and relapse (flare)Trindade, 2021. Inflammation can affect any organ and, if untreated, is associated with risks of organ- or body-system failure. Onset of SLE in adolescence is associated with more active and severe disease, greater potential for complications, and increased exposure to systemic corticosteroid drugs and their adverse effectsMassias, 2020.
For advice about reproductive health (particularly contraception) in people with SLE, see Reproductive health in people with SLE.