Intensive induction therapy for Takayasu arteritis
The appropriate route of administration and dosage of systemic corticosteroids for inducing remission in Takayasu arteritis depends on the disease severity. Patients suspected of having active or severe inflammation associated with Takayasu arteritis require initial intensive induction therapy with pulse intravenous methylprednisolone; the usual dosage is:
methylprednisolone sodium succinate 0.5 to 1 g intravenously, over 1 hour, daily for 3 days, then switch to oral prednisolone (or prednisone) as below. methylprednisolone sodium succinate methylprednisolone methylprednisolone
For patients with Takayasu arteritis who have less-severe disease, the usual dosage of oral corticosteroids is:
prednisolone (or prednisone) 1 mg/kg up to 80 mg orally, daily for a minimum of 4 weeks. Depending on tolerability, the dose may be given in 2 divided doses. prednis ol one prednis(ol)one prednis(ol)one