Tranexamic acid

Tranexamic acid is an antifibrinolytic drug that inhibits clot breakdown by preventing activation of plasminogen and plasmin. It reduces blood loss more than nonsteroidal anti-inflammatory drugs (NSAIDs) or oral progestogens.

Dosage varies, according to the heaviness and duration of bleeding. Use:

Tranexamic acid is well tolerated. Limited studies suggest it reduces flooding, leakage and sexual difficulties. The main adverse effects are nausea and gastrointestinal upset. It has fewer adverse events than oral progestogens. Caution is suggested in individuals predisposed to thromboembolic effects, although studies have not shown an increased risk of venous thromboembolism.

Tranexamic acid can be combined with hormonal treatment or NSAIDs.