Clinical presentation

Effects of NSAID poisoning include:

• gastrointestinal effects—nausea, vomiting, transient gastro-oesophageal irritation and inflammation
• metabolic effects—metabolic acidosis (ibuprofen ingestions of more than 400 mg/kg)
• kidney effects—acute kidney injury particularly in dehydrated patients; renal tubular acidosis and life-threatening hypokalaemia associated with chronic ibuprofen use
• central nervous system effects (uncommon)—seizures (mefenamic acid ingestions of more than 25 mg/kg), coma (ibuprofen ingestions of more than 1 g/kg).