Key references: Antipsychotic drug poisoning

  • Australian and New Zealand Committee on Resuscitation. Cardiorespiratory arrest flowcharts. East Melbourne: Australian Resuscitation Council; 2016. https://resus.org.au/guidelines/flowcharts-3/
  • Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. J Toxicol Clin Toxicol 2001;39(1):1–14. https://www.ncbi.nlm.nih.gov/pubmed/11327216
  • Cobaugh DJ, Erdman AR, Booze LL, Scharman EJ, Christianson G, Manoguerra AS, et al. Atypical antipsychotic medication poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2007;45(8):918–42. https://www.ncbi.nlm.nih.gov/pubmed/18163235
  • Dassanayake TL, Jones AL, Michie PT, Carter GL, McElduff P, Stokes BJ, et al. Risk of road traffic accidents in patients discharged following treatment for psychotropic drug overdose: a self-controlled case series study in Australia. CNS Drugs 2012;26(3):269–76. https://www.ncbi.nlm.nih.gov/pubmed/22329565
  • Dassanayake TL, Michie PT, Jones AL, Mallard T, Whyte IM, Carter GL. Cognitive skills underlying driving in patients discharged following self-poisoning with central nervous system depressant drugs. Traffic Inj Prev 2012;13(5):450–7. https://www.ncbi.nlm.nih.gov/pubmed/22931174
  • Findling RL, Goldman R, Chiu YY, Silva R, Jin F, Pikalov A, et al. Pharmacokinetics and tolerability of lurasidone in children and adolescents with psychiatric disorders. Clin Ther 2015;37(12):2788–97. https://www.ncbi.nlm.nih.gov/pubmed/26631428
  • Forrester MB. Lurasidone ingestions reported to Texas poisons centers. J Pharm Technol 2014;30(4):125–9. https://journals.sagepub.com/toc/pmta/30/4
  • Hawkins DJ, Unwin P. Paradoxical and severe hypotension in response to adrenaline infusions in massive quetiapine overdose. Crit Care Resusc 2008;10(4):320–2. https://www.ncbi.nlm.nih.gov/pubmed/19049484
  • Henderson RA, Lane S, Henry JA. Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose. Hum Exp Toxicol 1991;10(1):59–62. https://www.ncbi.nlm.nih.gov/pubmed/1673626
  • Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: a systematic review. Drug Saf 2005;28(11):1029–44. https://www.ncbi.nlm.nih.gov/pubmed/16231955
  • Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol 2010;30(4):391–5. https://www.ncbi.nlm.nih.gov/pubmed/20531221
  • Isbister GK, Duffull SB. Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol 2009;24(4):174–80. https://www.ncbi.nlm.nih.gov/pubmed/19494786
  • Isbister GK, Murray L, John S, Hackett LP, Haider T, O’Mullane P, et al. Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes. Med J Aust 2006;184(7):354–6. https://www.ncbi.nlm.nih.gov/pubmed/16584372
  • Klein-Schwartz W, Lofton AL, Benson BE, Spiller HA, Crouch BI. Prospective observational multi-poison center study of ziprasidone exposures. Clin Toxicol (Phila) 2007;45(7):782–6. https://www.ncbi.nlm.nih.gov/pubmed/17926152
  • Lackey G, Alsop J, Albertson T. A one-year review of pediatric ziprasidone ingestions [Abstract 62]. J Toxicol Clin Toxicol 2002;40(5):624. https://doi.org/10.1081/CLT-120016861
  • Melhem S, Katz K, Jameson A, Shellenbarger D, Akhtar J. Prolonged toxicity in a 2-year-old after accidental ingestion of aripiprazole. Pediatr Emerg Care 2009;25(2):105–6. https://www.ncbi.nlm.nih.gov/pubmed/19225379
  • Meli M, Rauber-Luthy C, Hoffmann-Walbeck P, Reinecke HJ, Prasa D, Stedtler U, et al. Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data. Eur J Pediatr 2014;173(6):743–50. https://www.ncbi.nlm.nih.gov/pubmed/24370666
  • Page CB, Calver LA, Isbister GK. Risperidone overdose causes extrapyramidal effects but not cardiac toxicity. J Clin Psychopharmacol 2010;30(4):387–90. https://www.ncbi.nlm.nih.gov/pubmed/20631557
  • Stassinos G, Klein-Schwartz W. Asenapine, iloperidone and lurasidone exposures in young children reported to U.S. poison centers. Clin Toxicol (Phila) 2018;56(5):355–9. https://www.ncbi.nlm.nih.gov/pubmed/28992737
  • Tsay ME, Klein-Schwartz W, Anderson B. Toxicity and clinical outcomes of paliperidone exposures reported to U.S. Poison Centers. Clin Toxicol (Phila) 2014;52(3):207–13. https://www.ncbi.nlm.nih.gov/pubmed/24580061