Mild or moderate invasive amoebiasis

For mild to moderate diarrhoea caused by Entamoeba histolytica, use:

1metronidazole 600 mg (child: 15 mg/kg up to 600 mg) orally, 8-hourly for 7 days metronidazole metronidazole metronidazole

OR

1tinidazole 2 g (child: 50 mg/kg up to 2 g) orally, daily for 3 days12. For dosage adjustment in adults with kidney impairment, see tinidazole dosage adjustment tinidazole tinidazole tinidazole

FOLLOWED BY (with either of the above drugs)

paromomycin 500 mg (child: 10 mg/kg up to 500 mg) orally, 8-hourly for 7 days3. For dosage adjustment in adults with kidney impairment, see paromomycin dosage adjustment. paromomycin paromomycin paromomycin

1 Tinidazole is not registered for use in Australia but is available via the Special Access Scheme.Return
2 Tinidazole is not available as a liquid formulation. If tinidazole dosing is difficult in children, use metronidazole.Return
3 Paromomycin is not registered for use in Australia but is available via the Special Access Scheme.Return