Treatment

Fluconazole is the preferred treatment for oropharyngeal candidiasis adults with HIV infection. Use:

fluconazole 50 to 100 mg orally, daily for 7 to 14 days until symptoms resolve. For dosage adjustment in adults with kidney impairment, see fluconazole dosage adjustment. candidiasis, oropharyngeal (adult with HIV) fluconazole fluconazole fluconazole

Use the higher dose of fluconazole for more severe disease.

If fluconazole is not suitable, use:

1 itraconazole (Lozanoc capsule) 50 mg orally, daily for 7 to 14 days until symptoms resolve¹ candidiasis, oropharyngeal (adult with HIV) itraconazole (capsule) itraconazole itraconazole

OR (if an oral liquid formulation is required)

1 itraconazole (Sporanox oral liquid) 100 mg orally, daily for 7 to 14 days until symptoms resolve¹ itraconazole itraconazole itraconazole

2 nystatin liquid 100 000 units/mL 1 mL topically (then swallowed), 6-hourly for 7 to 14 days until symptoms resolve. candidiasis, oropharyngeal (adult with HIV) nystatin nystatin nystatin

In patients with newly diagnosed HIV, exclude other infections before starting antiretroviral therapy for HIV infection. For patients with HIV and oropharyngeal candidiasis but no other infection, start antiretroviral therapy as soon as possible (see Initial antiretroviral therapy for HIV infection in adults).

¹ Oral preparations of itraconazole are not bioequivalent; appropriate dosing and administration depends on the preparation.Return