Practical information on using isoniazid

Isoniazid is used as part of combination treatment for active Mycobacterium tuberculosis infection and other mycobacterial infections. It is also used to treat latent tuberculosis as monotherapy or in combination with other antituberculosis drugs.

Although peripheral neuropathy can occur with isoniazid, the risk is minimised by co-administration with pyridoxine. Severe hepatitis has been reported with isoniazid; the risk is greater in females, and increases with age, hazardous alcohol consumption and pre-existing liver disease.