Endocarditis prophylaxis for dermatological or musculoskeletal procedures

For patients with a cardiac condition listed here  who are undergoing a surgical procedure involving infected skin, skin structures or musculoskeletal tissues, it is reasonable to include an antibiotic active against staphylococci and beta-haemolytic streptococci in the empirical antibiotic treatment regimen (eg an antistaphylococcal penicillin or a cephalosporin). Adjust the timing of therapy so that an oral dose is administered 60 minutes before the procedure, an intramuscular dose 30 minutes before the procedure, or an intravenous dose within the 60 minutes before the procedure.

Other dermatological or musculoskeletal procedures do not require endocarditis prophylaxis. However, surgical antibiotic prophylaxis may be indicated even if endocarditis prophylaxis is not—see Surgical antibiotic prophylaxis for specific procedures.