Initial intravenous therapy for nontyphoidal Salmonella enteritis in children

The regimens below are only suitable for children 1 month or older; seek expert advice for neonates with nontyphoidal Salmonella enteritis.

If antibiotic therapy is indicated for nontyphoidal Salmonella enteritis in children and initial intravenous therapy is required, useWen, 2017:

1ceftriaxone (child 1 month or older) 100 mg/kg up to 2 g intravenously, daily; for children with septic shock or requiring intensive care support, use 50 mg/kg up to 2 g intravenously, 12-hourly. See advice on modification and duration of therapy ceftriaxone

OR

1cefotaxime 50 mg/kg up to 2 g intravenously, 6-hourly. See advice on modification and duration of therapy cefotaxime

OR

1ciprofloxacin 10 mg/kg up to 400 mg intravenously, 12-hourly1; for children with septic shock or requiring intensive care support, use 10 mg/kg up to 400 mg intravenously, 8-hourly. See advice on modification and duration of therapy. ciprofloxacin

1 Ciprofloxacin is not licensed for use in children on the basis of animal studies that showed an adverse effect on cartilage development with quinolone use; however, clinical trial data suggest that adverse musculoskeletal events are usually mild and short term, similar to those observed in adults. Ciprofloxacin can be used in children when it is the drug of choice.Return