Vancomycin continuous infusion dosing in young infants not initially treated with an intermittent vancomycin infusion

For young infants aged 0 to 90 days not initially treated with intermittent vancomycin infusion, the continuous infusion should be immediately preceded by a loading dose; use:

vancomycin intravenously (loading dose)vancomycin

15 mg/kg (actual body weight) up to 1 g given over 1 hour as a single dose

FOLLOWED BY

vancomycin intravenously (initial continuous infusion dose)

see dose listed in Initial vancomycin continuous infusion dosing in young infants.

Young infants on a vancomycin continuous infusion should have a random plasma concentration measured 24 hours after starting the infusion – see Vancomycin trough plasma concentration monitoring in young infants and children.

Table 1. Initial vancomycin continuous infusion dosing in young infants
Gwee, 2019
Serum creatinine	Corrected gestational age [NB1]	Dose [NB2]
less than 40 micromol/L	less than 40 weeks	40 mg/kg/day
less than 40 micromol/L	40 weeks or more	50 mg/kg/day
40 to 60 micromol/L	all	30 mg/kg/day
more than 60 micromol/L	all	20 mg/kg/day
Note: NB1: Corrected gestational age = postnatal age (time since birth) – weeks of prematurity. NB2: The dosages recommended in this table should be administered over 24 hours.