Amiodarone for rate control of atrial fibrillation

Consider amiodarone for rate control of atrial fibrillation in patients with a left ventricular ejection fraction of 40% or less, or if beta blockers, nondihydropyridine calcium channel blockers or digoxin are contraindicated, not tolerated or do not control heart rateHindricks, 2021. Amiodarone is not well tolerated so it is usually used short term for rate control and added to other drugs by a cardiologist. A suitable regimen is:

amiodarone 200 mg orally, 3 times daily for 4 weeks, then 200 mg once dailyHindricks, 2021. amiodarone amiodarone amiodarone

The loading and maintenance doses of amiodarone must be adjusted according to patient response, tolerability and body weight, because of wide interpatient variability in absorption.