Statin-induced rhabdomyolysis

Statin-induced rhabdomyolysis is a rare but life-threatening adverse effect of statins that has been reported in about 1 to 3 patients in 100 000 patients per yearCatapano, 2016Collins, 2016. If a patient presents with severe myalgia or myalgia associated with general muscle weakness, measure serum CK concentration and perform urinalysis to detect myoglobinuria. The serum CK concentration is typically elevated by at least 10 times the ULN. Do not restart statin therapy in patients who had confirmed rhabdomyolysis.