Dosage of apixaban

Apixaban is a direct factor Xa inhibitor that is taken orally. Apixaban is significantly excreted via the kidneys so should not be used for patients with a calculated creatinine clearance (CrCl) less than 25 mL/min or severe liver impairment.

The dosage of apixaban varies according to the indication. For example:

• venous thromboembolism prophylaxis following hip or knee replacement
• venous thromboembolism treatment
• stroke prevention in patients with atrial fibrillation.

For advice on periprocedural interruption of apixaban therapy, see Periprocedural use of direct-acting oral anticoagulants (DOACs).