Dosage of dabigatran

Dabigatran is a direct thrombin (factor IIa) inhibitor that is taken orally. Dabigatran is predominantly excreted via the kidneys so it should not be used for patients with a calculated creatinine clearance (CrCl) less than 30 mL/min or severe liver impairment.

The dosage of dabigatran varies according to the indication. For example:

• venous thromboembolism prophylaxis following hip or knee replacement
• venous thromboembolism treatment
• stroke prevention in patients with atrial fibrillation.

For advice on periprocedural interruption of dabigatran therapy, see Periprocedural use of direct-acting oral anticoagulants (DOACs).