Confirm cure of hepatitis C (sustained virological response)

It is important to confirm that cure of hepatitis C has been achieved. Test hepatitis C virus (HCV) RNA using a highly sensitive polymerase chain reaction (PCR) assay at least 12 weeks after completion of direct-acting antiviral therapy. An undetectable HCV RNA at this time indicates cure of hepatitis C (sustained virological response [SVR]).

For patients who are not cured, retreatment should be considered in all cases where possible—see Treatment of adults who are not cured with first-line therapy for details.