Which patients to refer for specialist management

Refer or seek expert advice about management in the following patient groups or situations:

• children
• patients with suspected or proven cirrhosis (see Assess for the presence of cirrhosis)
• patients with complex comorbidities including co-infection with hepatitis B or HIV, significant kidney impairment, or other types of liver disease
• previous treatment failure with direct-acting antiviral therapy
• potential drug interactions that cannot be managed in primary care (see drug interactions with direct-acting antiviral drugs).