Key references: Titrating and withdrawing antiepileptic drugs

  • Beghi E, Gatti G, Tonini C, Ben-Menachem E, Chadwick DW, Nikanorova M, et al. Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial. Epilepsy Res 2003;57(1):1–13. https://www.ncbi.nlm.nih.gov/pubmed/14706729
  • Chadwick D, Taylor J, Johnson T. Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. The MRC Antiepileptic Drug Withdrawal Group. Epilepsia 1996;37(11):1043–50. https://www.ncbi.nlm.nih.gov/pubmed/8917053
  • Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, et al. Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis. Lancet Neurol 2017;16(7):523–31. https://www.ncbi.nlm.nih.gov/pubmed/28483337