Melatonin use during pregnancy

Melatonin use during pregnancy should be guided by the considerations outlined in Principles of psychotropic use during pregnancy.

Avoid using melatonin in pregnancy; safety data in humans is lacking. Endogenous melatonin is known to cross the placenta, and is thought to play a role in the development of the fetus’ circadian rhythm. Results from animal studies are mixed, with some indicating reduced birth weight and prolonged gestation.