Key references: Summary of inhalational drug delivery devices

  • Castro-Rodriguez JA, Rodrigo GJ. beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or asthma in children under 5 years of age: a systematic review with meta-analysis. J Pediatr 2004;145(2):172–7. https://www.ncbi.nlm.nih.gov/pubmed/15289762
  • Schultz A, Le Souef TJ, Venter A, Zhang G, Devadason SG, Le Souef PN. Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children. Pediatrics 2010;126(6):e1493–8. https://www.ncbi.nlm.nih.gov/pubmed/21078734