Intensive induction therapy for ANCA-associated vasculitides
For an overview of high-dose systemic corticosteroid use for the management of systemic vasculitides, see Systemic corticosteroids for severe systemic vasculitis.
High-dose systemic corticosteroids are used for intensive induction therapy in ANCA-associated vasculitides and at lower doses for maintenance of remission. Systemic corticosteroids often need to be continued for 2 years or more. Use the lowest dose and shortest duration of corticosteroid therapy necessary to control disease and prevent relapse because long-term therapy can cause significant adverse effects.
Combination therapy is often required for intensive induction therapy for ANCA-associated vasculitides. This usually involves either cyclophosphamide or rituximab in addition to systemic corticosteroids.