Other therapy for ANCA-associated vasculitides

For the management of severe, rapidly progressive sight-, organ- or life-threatening ANCA-associated vasculitides, plasma exchange may be considered on an individual basis. The key study1 about plasma exchange for patients with ANCA-associated vasculitidesWalsh, 2020 did not include patients with life-threatening disease, so conclusions cannot be made about this groupWalsh, 2020. Plasma exchange may still be considered for patients with acute kidney failure (with a serum creatinine concentration of more than 500 micromol/L) or pulmonary haemorrhageYates, 2016.

1 Walsh M, Merkel PA, Peh CA, Szpirt WM, Puechal X, Fujimoto S, et al. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis. N Engl J Med 2020;382(7):622-31. [URL]Return